I gave up a Mercedes for the Crosstour. Although I don't regret it, there is quite a bit that I left behind when I left the Mercedes. What I left behind wasn't enough to keep me in the Mercedes in the first place, though, so I am fine with that.
What's different? The handling. The build quality. The ride. There's fit and form in the Mercedes that is difficult to explain without experiencing a Mercedes first-hand. That said, the Crosstour is a heck of a vehicle and I'm glad I own it over the Mercedes. As I said elsewhere, thank goodness for no more $400 oil changes! But, as an example, Mercedes designers actually consider how much finger pressure is required to press a button on the radio (for example) and tweak the button to be at a specific sensitivity. Each and every button is set to the same pressure requirements to be activated. That's an amazing level of detail.
I imagine the Acura is similar. There is quite a bit of detail that goes into luxury vehicles that just doesn't show up on "regular" cars, but those details aren't always what's most important. It's a balancing act that each of us has to deal with on some level: price versus function/form. For example, I believe one of the features I saw on a 2010 Acura was a GPS assisted air conditioning unit. The A/C would consider the vehicle's position on the planet relative to the sun to figure out the best way to maintain the driver-set cabin temperature. You won't find a level of detail like that in the Crosstour (or most other "regular" vehicles for that matter).